Erica Lehman, MD PRO HEALTH GROUP, INC. TEL: (310) 504-3700 FAX: (310) 919-1199

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ABOUT LYME

Reasons Why Someone Could

Have A False-Negative Lyme Test

 

Dr. Robert Bransfield

 

1. Recent infection- before immune response has had time to produce antibodies

 

2. Antibodies are bound in immune complexes

 

3. Spirochete encapsulated by host tissue (i.e. lymphocytic cell walls)

 

4. Spirochete is deep in host tissue (i.e. fibroblasts, neurons, etc.)

 

5. Blebs in body fluid, no whole organisms needed for PCR

 

6. No spirochetes in body fluid on day of test

 

7. Genetic heterogeneity (300 strains, 100 in U.S.)

 

8. Antigenic variability

 

9. Surface antigens change with temperature

 

10. Utilization of host protease instead of microbial protease

 

11. Spirochete in dormancy phase (L-form) with no cell walls

 

12. Recent antibiotic treatment for any condition

 

13. Recent anti-inflammatory treatment

 

14. Concomitant infection with Babesia may cause immunosuppression

 

15. Other causes of immunosuppression

 

16. Lab with poor technical capability for Lyme disease

 

17. Lab tests not standardized for late stage disease

 

18. Lab tests labeled "for investigational use only"

 

19. CDC criteria is epidemiological and is not a diagnostic criteria

 

20. Lack of standardized control

 

21. Most controls use only a few strains as a reference point

 

22. Few organisms are present

 

23. Encapsulated by glycoprotein "S-layer" which impairs immune recognition

 

24. "S"- layer binds to IgM

Contact Us

 

125 North Robertson Boulevard

Beverly Hills, CA 90211

Tel: (310) 504-3700

Fax: (310) 919-1199

Dr. Erica Lehman

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DISCLAIMER: Content on this site is not intended to constitute a medical diagnosis or treatment. Please see a medical professional in order to obtain specific advice for your medical conditions.