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Erica Lehman, MD


Reasons Why Someone Could Have A False-Negative Lyme Test


Next Generation of Lyme disease Testing presented by Joseph Burrascano, MD and Jyotsna Shah, PhD


24 Reasons By Dr. Robert Bransfield


1. Recent infection- before immune response has had time to produce antibodies


2. Antibodies are bound in immune complexes


3. Spirochete encapsulated by host tissue (i.e. lymphocytic cell walls)


4. Spirochete is deep in host tissue (i.e. fibroblasts, neurons, etc.)


5. Blebs in body fluid, no whole organisms needed for PCR


6. No spirochetes in body fluid on day of test


7. Genetic heterogeneity (300 strains, 100 in U.S.)


8. Antigenic variability


9. Surface antigens change with temperature


10. Utilization of host protease instead of microbial protease


11. Spirochete in dormancy phase (L-form) with no cell walls


12. Recent antibiotic treatment for any condition


13. Recent anti-inflammatory treatment


14. Concomitant infection with Babesia may cause immunosuppression


15. Other causes of immunosuppression


16. Lab with poor technical capability for Lyme disease


17. Lab tests not standardized for late stage disease


18. Lab tests labeled "for investigational use only"


19. CDC criteria is epidemiological and is not a diagnostic criteria


20. Lack of standardized control


21. Most controls use only a few strains as a reference point


22. Few organisms are present


23. Encapsulated by glycoprotein "S-layer" which impairs immune recognition


24. "S"- layer binds to IgM

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